Key result
A urinary albumin/uromodulin ratio over 0.94 is linked to lower eGFR and rapid CKD progression.
Why the study?
Prevention of chronic kidney disease (CKD) development and rapid progression are key priorities, prompting the evaluation of urinary albumin to urinary uromodulin ratio alongside eGFR and Charlson Comorbidity Index to assess risk in stage 1–3 CKD.
Does the urinary albumin to urinary uromodulin ratio correlate with eGFR to predict the rapid progression of CKD in patients with stage 1-3 CKD?
Observational (n=123)
Does the urinary albumin to urinary uromodulin ratio correlate with eGFR to predict the rapid progression of CKD in patients with stage 1-3 CKD?
Effect estimate: R -0.295 to -0.32
p-value: p=< 0.05
A urinary albumin to urinary uromodulin ratio greater than 0.94 may serve as a non-invasive biomarker to identify patients with stage 1-3 chronic kidney disease at risk for rapid progression.
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uAlb/uUmod ratio >0.94 may signal rapid CKD progression risk in stages 1–3; hypothesis-generating and requires prospective validation before any clinical adoption.
Denova et al. (2025) conducted an observational in Chronic kidney disease (n=123). Urinary albumin/urinary uromodulin (uAlb/uUmod) ratio was evaluated on Correlation between uAlb/uUmod and eGFR (R -0.295 to -0.32, p=< 0.05). A urinary albumin/uromodulin ratio > 0.94 indicates a risk of rapid progression of chronic kidney disease, showing a significant inverse correlation with eGFR (p < 0.05).
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