Key result
An adult with varicella developed pulmonary embolism associated with transient significant levels of aCL and IgM anti-beta2-GPI antibodies, which resolved after two months.
Case Report (n=1)
Transient anti-beta2-GPI antibodies may be associated with acute VZV infection and could play a direct pathogenic role in thrombotic events such as pulmonary embolism.
Transient aPL antibodies warrant consideration in adult varicella with thrombosis; leaves open a causal role and need for prospective studies.
Anti-beta2-glycoprotein I antibodies are considered as a specific marker for the antiphospholipid syndrome. In contrast to lupus circulating anticoagulant and anticardiolipin (aCL) antibodies, they are usually not found at significant levels in infections. We report a case of pulmonary embolism in an adult with varicella. Transient significant levels of aCL antibodies and of IgM anti-beta2-GPI antibodies were observed. No other prothrombotic factor, including free protein S antigen deficiency, was found. The direct pathogenic role of these transient antibodies on the thrombotic event may then be suspected. They are probably associated with VZV acute infection and are absent two months after varicella.
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Viseux et al. (2000) conducted a case report in Pulmonary embolism and varicella (chicken pox) (n=1). Varicella infection and transient anti-beta2-GPI antibodies was evaluated on Pulmonary embolism and presence of antibodies. An adult with varicella developed pulmonary embolism associated with transient significant levels of aCL and IgM anti-beta2-GPI antibodies, which resolved after two months.
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