Key result
Naltrexone opioid detoxification is linked to a ~400% increase in sympathetic activity and plasma catecholamines.
Why the study?
Does heart rate variability correlate with plasma catecholamines during opioid detoxification in opioid-dependent patients?
Population
15 patients total: 8 opioid-dependent patients undergoing rapid opioid detoxification under propofol…
Comparison
Naltrexone treatment during propofol anesthesia vs Nonopioid-dependent controls monitored during…
Design
Cohort
Follow-up
During detoxification procedure
Authors
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HRV may noninvasively track sympathetic surges in opioid withdrawal; leaves open its clinical utility pending larger prospective studies.
Observational (n=15)
Does heart rate variability correlate with plasma catecholamines during opioid detoxification in opioid-dependent patients?
p-value: p=< .05
Heart rate variability provides a noninvasive method to evaluate sympathetic activation and reversal of opioid binding during rapid opioid detoxification.
McDonald et al. (1999) conducted an observational in Opioid dependence (n=15). Opioid detoxification with naltrexone vs. Nonopioid-dependent controls without naltrexone treatment was evaluated on Plasma catecholamines and sympathetic activity (SYMP) (p=< .05). Opioid detoxification with naltrexone increased plasma catecholamines and sympathetic activity by 300 to 400% (P < .05), confirming heart rate variability as a method to evaluate withdrawal.
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