Key result
Ultrarapid opiate detoxification prevented dramatic autonomic nervous system activation, with only transient changes in norepinephrine and no significant changes in epinephrine or dopamine.
Why the study?
Does ultrarapid opiate detoxification prevent adrenergic changes in patients with heroin abuse?
Population
43 patients with more than 6 years of heroin abuse seeking detoxification
Design
Cohort
Follow-up
6 months
Authors
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Deep sedation during ultrarapid detoxification was associated with transient norepinephrine reduction; leaves open whether this modifies withdrawal outcomes or abstinence.
Observational (n=43)
Does ultrarapid opiate detoxification prevent adrenergic changes in patients with heroin abuse?
Ultrarapid opiate detoxification with deep sedation prevents the dramatic activation of the autonomic nervous system typically seen during heroin withdrawal.
Macedo et al. (2000) conducted an observational in Heroin dependence (n=43). Ultrarapid heroin detoxification vs. Baseline was evaluated on Plasma catecholamines (norepinephrine, epinephrine, dopamine) and 5-HT levels. Ultrarapid opiate detoxification prevented dramatic autonomic nervous system activation, with only transient changes in norepinephrine and no significant changes in epinephrine or dopamine.
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