Key result
Hoffman Index rises ~110% during opioid detoxification and strongly correlates with time.
Why the study?
During rapid opioid detoxification, increased sympathetic activity and greater median EEG frequency have been reported, but a combined index to evaluate detoxification was not established.
Does the Hoffman Index better indicate the onset and maximum response of opioid detoxification compared to median EEG frequency or sympathetic activity alone in patients undergoing rapid opioid detoxification?
Comparison
Hoffman Index combining sympathetic activity and median EEG frequency vs median EEG frequency or sympathetic activity alone
Design
Observational study
Follow-up
24 hours
Authors
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May support Hoffman Index monitoring in rapid opioid detoxification; hypothesis-generating from one case report and leaves open prospective validation.
Observational (n=8)
Does the Hoffman Index better indicate the onset and maximum response of opioid detoxification compared to median EEG frequency or sympathetic activity alone in patients undergoing rapid opioid detoxification?
Effect estimate: r = 0.89-0.94
The Hoffman Index, combining median EEG frequency and sympathetic activity, more clearly indicates the onset and maximum response to opioid detoxification than either measure alone.
McDonald et al. (2001) conducted an observational in Opioid detoxification (n=8). Rapid opioid detoxification with naloxone was evaluated on Peak increases in Hoffman Index, median frequency, and sympathetic activity (r = 0.89-0.94). The Hoffman Index, combining median EEG frequency and sympathetic activity, increased by 110% from baseline during opioid detoxification and correlated with time (r = 0.89-0.94).
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