Key result
Elevated CK-MB with normal CK is linked to higher in-hospital mortality and heart failure.
Why the study?
Does elevated CK-MB with normal total creatine kinase predict worse early prognosis in patients with suspected myocardial infarction?
Cohort (n=347)
Does elevated CK-MB with normal total creatine kinase predict worse early prognosis in patients with suspected myocardial infarction?
Elevated CK-MB with normal total CK in suspected MI identifies a high-risk 'microinfarction' group with increased in-hospital mortality and complications, warranting aggressive treatment.
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May identify higher-risk suspected MI patients for closer monitoring; hypothesis-generating and requires prospective validation before practice change.
Hong et al. (1986) conducted a cohort in Suspected myocardial infarction (n=347). Normal CK levels with elevated MB percentages vs. Normal CK levels and normal MB percentages was evaluated on In-hospital mortality and clinical complications. Among 347 patients with suspected MI, those with normal CK but elevated MB (n=40) had higher in-hospital mortality and more heart failure compared to patients with normal CK and MB (n=223).
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