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We investigated the contributions of circulating macrophages and lymphocytes to survival of a host exposed to high doses of PR8 influenza virus. It was determined that when using host survival as an index, suppression of these cells and/or their functions had little influence on survival. Interferon levels when measured in sera and lung tissue of mice, showed no significant alteration in irradiated animals. The sex of the animal and splenectomy similarly did not influence these results.
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Hellman et al. (1968) studied this question.
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