Key result
X-irradiation at 125 R reduced myxovirus-induced circulating interferon levels to 4-28% of control values, whereas interferon induction by encephalomyocarditis or vaccinia viruses was radioresistant.
Why the study?
Does X-irradiation reduce circulating interferon induction by various viruses in mice?
Population
C3H/He mice
Comparison
Total-body X-irradiation followed by virus… vs Control animals (non-irradiated)
Design
Preclinical
Follow-up
4 days after exposure
Authors
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May indicate lymphocyte involvement in myxovirus interferon induction in mice; leaves open translation to humans.
Does X-irradiation reduce circulating interferon induction by various viruses in mice?
The high radiosensitivity of myxovirus-induced circulating interferon production suggests lymphocyte involvement in interferon induction by these viruses.
Maeyer et al. (1969) studied X-irradiated C3H/He mice. X-irradiation vs. Control animals was evaluated on Circulating interferon induction. X-irradiation at 125 R reduced myxovirus-induced circulating interferon levels to 4-28% of control values, whereas interferon induction by encephalomyocarditis or vaccinia viruses was radioresistant.
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