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November 1, 1974Infection and ImmunityOpen Access

Interferon Synthesis in X-Irradiated Animals V. Origin of Mouse Serum Interferon Induced by Polyinosinic-Polycytidylic Acid and Encephalomyocarditis Virus

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Population

Rat-to-mouse radiation chimeras (irradiated C3H/He mice grafted with Wistar rat bone marrow cells)

Design

Preclinical

Follow-up

Up to 3 months after grafting

Authors

PJPierre JullienUniversité Paris-SudJMJaqueline De Maeyer‐GuignardUniversité Paris-SudEMEdward De MaeyerUniversité Paris-Sud

Discussion

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Overview

Distinguishes interferon cellular sources in animal models; leaves open translation to human antiviral strategies.

Structured PICO

P
Population
Rat-to-mouse radiation chimeras (irradiated C3H/He mice grafted with Wistar rat bone marrow cells)
I
Intervention
Intravenous administration of polyinosinic-polycytidylic acid [poly(I.C)] or encephalomyocarditis virus
O
Outcome
Origin/type of serum interferon (donor vs recipient type)surrogate

The bulk of poly(I.C)-induced circulating interferon originates from a macrophage/hemopoietic cell population, unlike encephalomyocarditis virus-induced interferon.

Cite This Study

Jullien et al. (1974) studied this question.

synapsesocial.com/papers/6a907b30cdfefb262bc7a25chttps://doi.org/10.1128/iai.10.5.1023-1028.1974
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interferon Synthesis in X-Irradiated Animals III. The High Radiosensitivity of Myxovirus-Induced Circulating Interferon Production1969 · 35 citations
  2. 2MYOSITIS IN MICE FOLLOWING INTRAMUSCULAR INJECTION OF VIRUSES OF THE MOUSE ENCEPHALOMYELITIS GROUP AND OF CERTAIN OTHER NEUROTROPIC VIRUSES1949 · 56 citations
  3. 3Host-Virus Relations in Encephalomyocarditis (EMC) Virus Infections1956 · 24 citations
  4. 4THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES1965 · 694 citations
  5. 5Interferon Synthesis in X-irradiated Animals1968 · 20 citations