Key result
Heparin and antithrombin III enable live delivery in protein C deficiency with recurrent fetal death.
Why the study?
Does heparin and antithrombin III administration prevent intrauterine fetal death in a pregnant woman with congenital protein C deficiency?
Case Report (n=1)
Does heparin and antithrombin III administration prevent intrauterine fetal death in a pregnant woman with congenital protein C deficiency?
Anticoagulation with heparin and antithrombin III may be an effective strategy to prevent recurrent intrauterine fetal death in patients with congenital protein C deficiency.
Answers are grounded in this paper and cite their sources.
May support anticoagulation in protein C-deficient pregnancies with prior loss; leaves open efficacy for preventing recurrent fetal death.
A 29-year-old woman experienced unexplained intrauterine fetal death (IUFD) three times, at 16, 27 and 27 gestational weeks. She was found to be protein C-deficient and the existence of infarction in the placenta was suspected at 20 weeks' gestation during her fourth pregnancy. Both heparin and antithrombin III were administered until delivery of a small-for-dates but live baby. Massive infarction in the placenta was evident at term. Anticoagulation with heparin is a useful treatment approach for cases of recurrent IUFD with protein C deficiency.
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Ogasawara et al. (1995) conducted a case report in Congenital protein C deficiency with recurrent pregnancy loss (n=1). Heparin and antithrombin III was evaluated on Delivery of a live baby. Administration of heparin and antithrombin III in a 29-year-old woman with protein C deficiency and recurrent intrauterine fetal death resulted in the delivery of a live baby.
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