Key result
Red wine or vodka increases resting ischemic perfusion versus diet alone in a swine model.
Why the study?
Does red wine or vodka improve collateral-dependent perfusion and cardiovascular function in a hypercholesterolemic swine model of chronic ischemia?
Population
Yorkshire swine fed a high-cholesterol diet with left circumflex ameroid constrictor placement to induce…
Comparison
Red wine or vodka supplemented for 7 weeks vs High-cholesterol diet alone
Design
Preclinical
Follow-up
7 weeks
Authors
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May support alcohol's perfusion benefits in ischemic models; leaves open human translation and practice change.
Does red wine or vodka improve collateral-dependent perfusion and cardiovascular function in a hypercholesterolemic swine model of chronic ischemia?
Moderate consumption of red wine and vodka improves collateral-dependent perfusion in ischemic myocardium through different mechanisms, with red wine offering additional antioxidant-related cardioprotection.
Chu et al. (2012) studied Chronic ischemia and hypercholesterolemia (n=26). Red wine or vodka vs. High-cholesterol diet alone was evaluated on Collateral-dependent perfusion and cardiovascular function. Supplementation with red wine or vodka significantly increased resting perfusion to the ischemic territory compared with diet alone in a swine model of chronic ischemia.
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