Key result
Supplemental resveratrol increased tissue blood flow during stress by 2.8-fold (P=0.04) and preserved regional wall motion in a swine model of chronic myocardial ischemia.
Why the study?
Does supplemental resveratrol improve cardiac perfusion in a swine model of hypercholesterolemia and chronic myocardial ischemia?
Population
21 Yorkshire swine. After 4 weeks of diet, an ameroid constrictor was placed on the left circumflex artery…
Comparison
Supplemental resveratrol 100 mg/kg/d orally… vs Hypercholesterolemic diet alone and normal diet.
Design
Preclinical
Follow-up
11 weeks (4 weeks pre-ischemia, 7 weeks post-ischemia)
Authors
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Hypothesis-generating for resveratrol in chronic ischemia; should not change practice pending human trials.
Does supplemental resveratrol improve cardiac perfusion in a swine model of hypercholesterolemia and chronic myocardial ischemia?
Effect estimate: 2.8-fold greater
p-value: p=0.04
Supplemental resveratrol improves myocardial perfusion, preserves endothelial function, and upregulates angiogenesis markers in a swine model of chronic myocardial ischemia and hypercholesterolemia.
Robich et al. (2010) studied Hypercholesterolemia and chronic myocardial ischemia (n=21). Supplemental resveratrol vs. Hypercholesterolemic diet without resveratrol (HCC) and normal diet (control) was evaluated on Tissue blood flow during stress (2.8-fold greater, p=0.04). Supplemental resveratrol increased tissue blood flow during stress by 2.8-fold (P=0.04) and preserved regional wall motion in a swine model of chronic myocardial ischemia.
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