Key result
Oral nitroglycerin exhibits nonlinear absorption and metabolism, yielding distinct metabolite ratios at 0.4 mg.
Why the study?
How do the pharmacokinetics of nitroglycerin and its dinitrate metabolites vary across a thirtyfold range of oral doses in healthy volunteers?
Population
6 healthy volunteers
Comparison
Nitroglycerin oral solution in six doses ranging… vs Different doses of nitroglycerin and different…
Design
Other
Authors
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Dose nonlinearity may explain prior nitroglycerin metabolite differences attributed to route; leaves open effects on clinical dosing or efficacy.
How do the pharmacokinetics of nitroglycerin and its dinitrate metabolites vary across a thirtyfold range of oral doses in healthy volunteers?
This pharmacokinetic study suggests that differences in nitroglycerin metabolite ratios previously attributed to the route of administration (sublingual vs oral) may actually reflect differences in dose.
Nakashima et al. (1990) studied Healthy volunteers (n=6). Nitroglycerin oral solution was evaluated on Pharmacokinetics of nitroglycerin and its dinitrate metabolites (Cmax/dose and AUC/dose). Nitroglycerin absorption and metabolism exhibited nonlinearity between 0.4 mg and 13 mg oral doses, with the 0.4 mg dose producing a significantly different metabolite ratio than doses ≥1.6 mg.
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