Key result
Transderm-Nitro, Nitrodisc, and Nitro-Dur II deliver equivalent amounts of systemic nitroglycerin.
Why the study?
The pharmacokinetics and bioavailability of nitroglycerin and its metabolites from different transdermal delivery systems were compared to assess equivalence and metabolic differences.
Do different transdermal nitroglycerin systems (Transderm-Nitro, Nitrodisc, and Nitro-Dur II) deliver equivalent amounts of nitroglycerin into the systemic circulation in healthy male subjects?
Population
18 healthy male subjects
Comparison
Transderm-Nitro vs Nitrodisc vs Nitro-Dur II transdermal systems
Design
Pharmacokinetic study with simultaneous 15N-labeled intravenous infusion
Follow-up
14 hours
Authors
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May support patch interchangeability; leaves open confirmation in outcome trials.
Do different transdermal nitroglycerin systems (Transderm-Nitro, Nitrodisc, and Nitro-Dur II) deliver equivalent amounts of nitroglycerin into the systemic circulation in healthy male subjects?
Three different transdermal nitroglycerin systems (Transderm-Nitro, Nitrodisc, and Nitro-Dur II) deliver equivalent amounts of nitroglycerin into the systemic circulation.
Sun et al. (1995) studied Healthy (n=18). Transderm-Nitro, Nitrodisc, and Nitro-Dur II vs. Each other was evaluated on Total amounts of nitroglycerin transdermally available. Transderm-Nitro, Nitrodisc, and Nitro-Dur II systems delivered equivalent amounts of nitroglycerin into the systemic circulation during a 14-hour application.
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