Key result
Mild-to-moderate anemia is not independently linked to in-hospital or 31-day mortality in decompensated HF.
Why the study?
Does mild-to-moderate anemia independently increase short-term mortality in hospitalized patients with decompensated NYHA class III/IV chronic heart failure?
Cohort (n=725)
Does mild-to-moderate anemia independently increase short-term mortality in hospitalized patients with decompensated NYHA class III/IV chronic heart failure?
Mild-to-moderate anemia appears to be a marker of an adverse baseline risk profile rather than an independent contributor to short-term mortality in patients with decompensated severe heart failure.
Does not support anemia-directed interventions to reduce short-term mortality in decompensated HF; leaves open causal effects in prospective trials.
OBJECTIVES: The possible independent effect of mild-to-moderate anemia (hemoglobin value not <9 g/dl) on the short-term mortality of patients with decompensation of NYHA class III/IV chronic heart failure has not been investigated yet. METHODS: A total of 725 consecutive hospitalized patients were studied. All-cause mortalities during hospitalization and by day 31 were the prespecified study end points. RESULTS: A total of 76 (10.5%) and 133 (18.3%) patients died during hospital stay and by day 31 of follow-up, respectively. Patients in the first hemoglobin tertile were at a significantly higher risk of death than those in the second (p = 0.003 and p < 0.001 for unadjusted in-hospital and 31-day mortality, respectively) or third terile (p < 0.001 and p < 0.001, for unadjusted in-hospital and 31-day mortality, respectively). However, after adjustment for concomitant baseline comorbidities and biochemical parameters, there was no significant difference in the risk of death among hemoglobin tertiles. CONCLUSIONS: Mild-to-moderate anemia seems not to contribute independently to short-term mortality in patients with decompensation of NYHA class III/IV chronic heart failure. An adverse concomitant baseline risk profile may have a key role in the induction of mild-to-moderate anemia and in the increased risk of death in these patients.
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Zairis et al. (2011) conducted a cohort in Decompensation of NYHA class III/IV chronic heart failure (n=725). Mild-to-moderate anemia vs. Second and third hemoglobin tertiles was evaluated on All-cause mortality during hospitalization and by day 31. Mild-to-moderate anemia was not independently associated with in-hospital (10.5% overall) or 31-day (18.3% overall) mortality in patients with decompensated chronic heart failure after adjustment.
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