Key result
Anemia in heart failure is linked to higher mortality, plateauing above hemoglobin 140 g/L.
Why the study?
The prevalence of anemia and its association with comorbidities and clinical outcomes in patients with heart failure needed to be assessed.
Observational
No
Answers are grounded in this paper and cite their sources.
Anemia links to higher NYHA class in HF; hypothesis-generating for independent prognostic value in risk assessment.
The objective of this study was to assess the prevalence of anemia and to investigate its association with comorbidities and its impact on clinical outcomes in patients with heart failure. The association of predefined anemia, as well as the correlation of serum hemoglobin level as a continuous variable, with outcomes of emergency department visits, hospitalization, and mortality was investigated. There were fewer anemic patients in New York Heart Association classes I and II than in classes III and IV. Anemia was associated with higher rates of emergency department visits, hospital admissions, and all-cause mortality. Multivariable analysis showed that anemia is independently associated with mortality. When hemoglobin level was considered as a continuous variable, the authors noted that the mortality risk correlated with hemoglobin level disappears when hemoglobin level exceeds 140 g/L. The authors conclude that anemia has strong impacts on functional class and other clinical outcomes in patients with heart failure.
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Elabbassi et al. (2006) conducted an observational in Congestive heart failure. Anemia and serum hemoglobin level vs. Non-anemic patients / hemoglobin level >140 g/L was evaluated on Emergency department visits, hospitalization, and all-cause mortality. Anemia in heart failure patients was independently associated with mortality, though hemoglobin-correlated mortality risk disappeared above 140 g/L.
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