October 1, 1980Cardiovascular Research
Electrophysiological characteristics of rodent myocardium damaged by adrenaline
Key result
Subcutaneous l-adrenaline triggers abnormal ventricular electrophysiology and conduction disturbances in rodents.
Population
Rats and guinea pigs
Design
Preclinical
Follow-up
24 h after injection
Authors
Discussion
Loading...
Member takes
Implication
Adrenaline-induced changes may promote arrhythmias in injured myocardium; leaves open relevance to human catecholamine cardiomyopathy.
Structured PICO
P
Population
Rats and guinea pigs studied 24 hours after subcutaneous injection of 1-adrenaline to induce myocardial cell injury.
I
Intervention
3.0 mg.kg-1 l-adrenaline injected subcutaneously
O
Outcome
Electrophysiological alterations in ventricular myocardium in vitrosurrogate
Adrenaline-induced myocardial injury in rodents leads to significant electrophysiological alterations, including conduction disturbances and abnormal automaticity.
Cite This Study
Gilmour et al. (1980) studied Myocardial cell injury. 1-adrenaline was evaluated on Electrophysiological alterations (resting membrane potential, action potential, conduction disturbances, abnormal automatic activity). Subcutaneous injection of 1-adrenaline in rodents caused diverse abnormal electrophysiological alterations in the ventricular myocardium, including reduced resting membrane potential and conduction disturbances.