Key result
Preoperative estimated pulmonary arterial systolic pressure ≥47 mm Hg was significantly associated with an increased risk of postoperative MACEs (OR 1.62; 95% CI 1.01-2.23).
Why the study?
Pulmonary hypertension increases postoperative risk, but the relation between preoperative ePASP and postoperative cardiac outcomes, as well as a clinically meaningful ePASP threshold in postcapillary pulmonary hypertensive patients, required evaluation.
Does a preoperative ePASP ≥47 mm Hg increase the risk of postoperative MACEs in postcapillary pulmonary hypertensive patients undergoing elective noncardiac surgery?
Population
16,210 elective noncardiac surgeries in postcapillary pulmonary hypertensive patients
Comparison
ePASP above vs below the identified threshold
Design
Single-center retrospective cohort study with propensity score matching
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ePASP elevation was associated with higher MACE risk; leaves open whether thresholds should guide perioperative management in postcapillary PH.
Cohort (n=16,210)
No
Does a preoperative ePASP ≥47 mm Hg increase the risk of postoperative MACEs in postcapillary pulmonary hypertensive patients undergoing elective noncardiac surgery?
Odds Ratio: 1.62 (95% CI 1.01–2.23)
A preoperative echocardiographic estimated pulmonary arterial systolic pressure ≥47 mm Hg is an independent predictor of postoperative MACEs in patients with postcapillary pulmonary hypertension undergoing noncardiac surgery.
A 2022 study conducted a cohort in Postcapillary pulmonary hypertension undergoing noncardiac surgery (n=16,210). Preoperative ePASP ≥47 mm Hg vs. Preoperative ePASP <47 mm Hg was evaluated on Postoperative major adverse cardiac events (MACEs) (OR 1.62, 95% CI 1.01-2.23). Preoperative estimated pulmonary arterial systolic pressure ≥47 mm Hg was significantly associated with an increased risk of postoperative MACEs (OR 1.62; 95% CI 1.01-2.23).
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