Key result
Impaired glucose tolerance linked to higher 6-hour postprandial myocardial dietary fatty acid partitioning versus controls.
Why the study?
Does impaired glucose tolerance alter cardiac dietary fatty acid metabolism differently in men and women?
Observational
Does impaired glucose tolerance alter cardiac dietary fatty acid metabolism differently in men and women?
Impaired glucose tolerance increases postprandial cardiac dietary fatty acid partitioning in both men and women, though early uptake is higher in men due to chylomicron-triglyceride levels.
Answers are grounded in this paper and cite their sources.
Should not change clinical management of impaired glucose tolerance; hypothesis-generating for sex-independent cardiac fatty acid partitioning.
Oral 14(R,S)-[(18)F]-fluoro-6-thia-heptadecanoic acid was used to determine whether an increase in cardiac dietary fatty acid (DFA) metabolism in impaired glucose tolerance (IGT) is different in men and women. Myocardial DFA partitioning after 6 h was higher in IGT versus control subjects (P = 0.006) in both men (2.14 [95% CI 1.70-2.18] vs. 1.28 standard uptake value [SUV] units [0.80-1.76]) and women (1.95 [1.57-2.33] vs. 1.64 SUV units [1.32-1.96]) without difference between sexes. Myocardial DFA fractional uptake (Ki) between time 90 and 120 min postprandially was also higher in IGT versus control subjects (P < 0.001) in men (0.063 [0.032-0.095] vs. 0.016 min(-1) [0.007-0.025]) and women (0.050 [0.024-0.077] vs. 0.030 min(-1) [0.013-0.047]) without significant sex difference. Men had higher net myocardial DFA uptake between time 90 and 120 min driven by higher chylomicron-triglyceride (TG) levels. IGT-associated increased cardiac DFA partitioning was directly related to obesity in women, whereas it was associated with IGT per se in men. We conclude that early cardiac DFA uptake is higher in men driven by change in postprandial chylomicron-TG level but that increase in 6-h postprandial cardiac DFA partitioning nevertheless occurs with IGT both in men and women.
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Kunach et al. (2014) conducted an observational in Impaired glucose tolerance. Impaired glucose tolerance vs. Control subjects was evaluated on Myocardial dietary fatty acid (DFA) partitioning after 6 h (p=0.006). Impaired glucose tolerance was associated with higher 6-hour postprandial myocardial dietary fatty acid partitioning compared to controls in both men and women.
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