Key result
Intracoronary verapamil or BDM cuts external work by ~65% and shifts end-diastolic pressure-length relations rightward.
Population
15 open-chest anesthetized pigs
Comparison
Intracoronary verapamil or 2,3-butanedione… vs Untreated regions of the same hearts and…
Design
Preclinical
Authors
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Supports diastolic cross-bridge effects on ventricular mechanics in vivo; leaves open relevance to human diastolic dysfunction.
p-value: p=< 0.05
Residual diastolic cross-bridges significantly and reversibly influence end-diastolic mechanics in vivo, with alterations occurring in parallel with systolic cross-bridge interactions.
Lu et al. (2001) studied this question. Intracoronary verapamil or 2,3-butanedione monoxime (BDM) vs. Untreated regions of each heart was evaluated on End-diastolic pressure (EDP) versus end-diastolic segment length (EDL) relations (p=< 0.05). Intracoronary verapamil or BDM reduced external work to 31-38% of baseline and shifted end-diastolic pressure versus length relations to the right by an average of 5% (P < 0.05).
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