Key result
Calcium antagonists increased end-diastolic volume up to 40-80% at low end-diastolic pressure values, whereas BDM decreased it by about 5%.
Population
Isolated rat hearts perfused in a modified Langendorff perfusion system
Design
Preclinical
Authors
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Supports calcium-sensitive crossbridge effects on diastolic compliance in rat hearts; hypothesis-generating and leaves open human relevance.
At low end-diastolic pressures, diastolic volume in isolated rat hearts is dependent upon weakly bound crossbridges as a function of calcium concentration.
Schiereck et al. (1994) studied Isolated rat left ventricle. Calcium antagonists (verapamil, diltiazem, nifedipine) or Mg-ATPase blocker BDM was evaluated on End diastolic pressure-end diastolic volume (EDP-EDV) relationship. Calcium antagonists increased end-diastolic volume up to 40-80% at low end-diastolic pressure values, whereas BDM decreased it by about 5%.
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