Key result
Morning onset AMI is linked to a ~26% lower recanalization rate after r-SK thrombolysis.
Why the study?
Does the time of AMI onset (morning vs non-morning) affect the recanalization rate following intravenous recombinant streptokinase thrombolysis in patients with acute myocardial infarction?
Observational (n=114)
No
Does the time of AMI onset (morning vs non-morning) affect the recanalization rate following intravenous recombinant streptokinase thrombolysis in patients with acute myocardial infarction?
Absolute Event Rate: 60.4% vs 82%
p-value: p=<0.05
Morning onset of acute myocardial infarction is associated with a lower recanalization rate following recombinant streptokinase thrombolysis, potentially due to higher PAI-1 antigen levels.
Should not yet alter thrombolysis protocols; leaves open whether circadian factors modify recanalization in prospective trials.
The aim of this study was to explore the chronergy of intravenous recombinant streptokinase (r-SK) in patients with acute myocardial infarction (AMI). A total of 114 patients were divided into two groups according to the time of AMI onset: the morning onset (6:01-12:00, n=53) and non-morning onset (12:01-06:00, n=61) groups. The recanalization rate was recorded, as well as anticoagulant and fibrinolytic indices. Statistical analysis was performed to evaluate the recanalization rate following thrombolysis, as well as the anticoagulant and fibrinolytic activities. The recanalization rates following thrombolysis in the morning onset and non-morning onset groups were 60.4 and 82.0%, respectively (P<0.05). The level of plasminogen activator inhibitor-1 (PAI-1) antigen was significantly higher in the morning onset group compared with that in the non-morning onset group (P<0.05). This indicated a resistance to r-SK thrombolysis in the morning at the early stage of AMI, which possibly correlates with increased PAI-1 antigen levels and activity.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2013) conducted an observational in Acute myocardial infarction (n=114). Morning onset of AMI (6:01-12:00) vs. Non-morning onset (12:01-06:00) was evaluated on Recanalization rate following thrombolysis (p=<0.05). Morning onset of acute myocardial infarction was associated with a significantly lower recanalization rate following recombinant streptokinase thrombolysis compared to non-morning onset (60.4% vs 82.0%, P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: