What is the clinical evidence from this study?

Study design: Cohort. Population: Critical illness requiring Intensive Care Unit (ICU) admission (n=850). Intervention: Maximum heart rate <100/min within 24 hours of admission vs. Maximum heart rate ≥100/min within 24 hours of admission. Primary outcome: ICU mortality (p=<0.001).

November 26, 2016Pakistan Journal of Medical SciencesOpen Access

Increased heart rate on first day in Intensive Care Unitis associated with increased mortality

Q: What are the key findings of this study?

A maximum heart rate of less than 100 beats per minute during the first 24 hours of ICU admission was associated with significantly lower ICU mortality compared to a heart rate of 100 or more (3% vs 10%, p<0.001).

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Key result

Maximum heart rate under 100 bpm on ICU day one linked to ~70% lower mortality.

P<0.001
n=850

Why the study?

Is a maximum heart rate ≥100/min on the first day of ICU admission associated with increased mortality in patients over 45 years of age?

Population

850 patients over 45 years of age hospitalized in the ICU.

Comparison

Maximum heart rate ≥100/min on the first day in… vs Maximum heart rate <100/min on the first day in…

Design

Cohort

Follow-up

Until hospital discharge

Authors

DKDuygu KaraMi̇lli̇ Eği̇ti̇m Bakanliği SASeda Banu AkıncıHacettepe University Hospital GBGülçin BabaoğluBilkent University

Discussion

Member takes

Implication

Maximum HR ≥100/min on ICU day 1 associated with higher mortality; hypothesis-generating for HR control trials in older adults.

Study Design

Type

Cohort (n=850)

Multicenter

Structured PICO

Is a maximum heart rate ≥100/min on the first day of ICU admission associated with increased mortality in patients over 45 years of age?

Population

850 mixed medical and surgical ICU patients aged 45 years and older, retrospectively analyzed to assess the association between maximum heart rate on admission and mortality.

Exposure

Maximum heart rate ≥100/min on the first day in ICU

Comparator

Maximum heart rate <100/min on the first day in ICU

Outcome

ICU mortalityhard clinical

Main Result

Absolute Event Rate: 3% vs 10%

p-value: p=<0.001

A maximum heart rate of ≥100 beats per minute on the first day of ICU admission is independently associated with increased ICU mortality.

Limitations

Retrospective and single-center study design.
Confounding drug history of some patients was not fully evaluated due to missing detailed drug history in some cases.
The population consisted mostly of hypotensive, postoperative, anemic patients with relatively lower APACHE-II scores and short ICU stays, which may influence the general applicability of the results.

Cite This Study

Kara et al. (2016) conducted a cohort in Critical illness requiring Intensive Care Unit (ICU) admission (n=850). Maximum heart rate <100/min within 24 hours of admission vs. Maximum heart rate ≥100/min within 24 hours of admission was evaluated on ICU mortality (p=<0.001). A maximum heart rate of less than 100 beats per minute during the first 24 hours of ICU admission was associated with significantly lower ICU mortality compared to a heart rate of 100 or more (3% vs 10%, p<0.001).

synapsesocial.com/papers/6aa44807d5ccfe0ebfb7312a https://doi.org/10.12669/pjms.326.11507

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November 26, 2016Pakistan Journal of Medical SciencesOpen Access

Increased heart rate on first day in Intensive Care Unitis associated with increased mortality

View Full Paper

Ask AI

Bookmark

Key result

Maximum heart rate under 100 bpm on ICU day one linked to ~70% lower mortality.

P<0.001
n=850

Why the study?

Is a maximum heart rate ≥100/min on the first day of ICU admission associated with increased mortality in patients over 45 years of age?

Population

850 patients over 45 years of age hospitalized in the ICU.

Comparison

Maximum heart rate ≥100/min on the first day in… vs Maximum heart rate <100/min on the first day in…

Design

Cohort

Follow-up

Until hospital discharge

Authors

DKDuygu KaraMi̇lli̇ Eği̇ti̇m Bakanliği SASeda Banu AkıncıHacettepe University Hospital GBGülçin BabaoğluBilkent University

Discussion

Member takes

Implication

Maximum HR ≥100/min on ICU day 1 associated with higher mortality; hypothesis-generating for HR control trials in older adults.

Study Design

Type

Cohort (n=850)

Multicenter

Structured PICO

Is a maximum heart rate ≥100/min on the first day of ICU admission associated with increased mortality in patients over 45 years of age?

Population

850 mixed medical and surgical ICU patients aged 45 years and older, retrospectively analyzed to assess the association between maximum heart rate on admission and mortality.

Exposure

Maximum heart rate ≥100/min on the first day in ICU

Comparator

Maximum heart rate <100/min on the first day in ICU

Outcome

ICU mortalityhard clinical

Main Result

Absolute Event Rate: 3% vs 10%

p-value: p=<0.001

A maximum heart rate of ≥100 beats per minute on the first day of ICU admission is independently associated with increased ICU mortality.

Limitations

Retrospective and single-center study design.
Confounding drug history of some patients was not fully evaluated due to missing detailed drug history in some cases.
The population consisted mostly of hypotensive, postoperative, anemic patients with relatively lower APACHE-II scores and short ICU stays, which may influence the general applicability of the results.

Cite This Study

synapsesocial.com/papers/6aa44807d5ccfe0ebfb7312a https://doi.org/10.12669/pjms.326.11507

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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