Key result
Amrinone and isoproterenol increase nonmechanical oxygen cost proportional to contractility without altering efficiency in rabbit hearts.
Why the study?
Does amrinone compared to isoproterenol alter left ventricular contractility and energetics in isolated blood-perfused rabbit hearts?
Population
Isolated cross-circulated (blood-perfused) rabbit hearts
Comparison
Amrinone infusion in constant-flow or… vs Isoproterenol infusion in constant-flow or…
Design
Preclinical
Authors
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Does not support clinical inotrope changes; leaves open translation of rabbit-heart energetics to humans.
Does amrinone compared to isoproterenol alter left ventricular contractility and energetics in isolated blood-perfused rabbit hearts?
Amrinone and isoproterenol have similar effects on cardiac energetic cost in rabbit hearts, increasing nonmechanical oxygen cost proportionally to contractility without altering contractile efficiency.
Goto et al. (1992) studied Isolated cross-circulated rabbit hearts. Amrinone vs. Isoproterenol was evaluated on Emax (ventricular contractility index) and VO2 intercept of the linear VO2-PVA relation. Amrinone and isoproterenol both increased the nonmechanical oxygen cost in proportion to the increase in contractility without changing contractile efficiency in isolated rabbit hearts.
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