Key result
Intravenous amrinone had effects on haemodynamics, contractility, and myocardial metabolism that did not differ significantly from the pure vasodilator sodium nitroprusside.
Why the study?
Does intravenous amrinone compared to sodium nitroprusside improve haemodynamics, contractility, and myocardial metabolism in patients with cardiac failure?
Population
14 patients with cardiac failure (8 with dilated cardiomyopathy and 6 with coronary artery disease)
Comparison
Intravenous amrinone vs Intravenous sodium nitroprusside
Design
Other
Authors
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Amrinone may lack direct inotropy beyond vasodilation in heart failure; leaves open need for outcome trials versus nitroprusside.
Does intravenous amrinone compared to sodium nitroprusside improve haemodynamics, contractility, and myocardial metabolism in patients with cardiac failure?
In patients with heart failure, intravenous amrinone acts primarily as a vasodilator similar to sodium nitroprusside, without demonstrating a direct positive inotropic effect.
Wilmshurst et al. (1984) studied Cardiac failure (n=14). Intravenous amrinone vs. Sodium nitroprusside was evaluated on Haemodynamic indices, left ventricular contractility, and myocardial metabolism. Intravenous amrinone had effects on haemodynamics, contractility, and myocardial metabolism that did not differ significantly from the pure vasodilator sodium nitroprusside.
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