August 1, 1986Circulation
Effect of amrinone on right ventricular function: predominance of afterload reduction.
Why the study?
Does intravenous amrinone improve right ventricular systolic function in patients with severe congestive heart failure?
Population
9 patients with severe congestive heart failure
Comparison
Short-term intravenous amrinone (3 mg/kg) vs Baseline and nitroprusside-derived right…
Design
Case_series
Follow-up
short-term
Authors
Discussion
Loading...
Member takes
Implication
May support short-term RV support in severe HF; hypothesis-generating and requires controlled trials before practice change.
Structured PICO
Does intravenous amrinone improve right ventricular systolic function in patients with severe congestive heart failure?
P
Population
9 patients with severe congestive heart failure
I
Intervention
Short-term intravenous amrinone (3 mg/kg)
C
Comparator
Baseline and nitroprusside-derived right ventricular end-systolic pressure-volume relationship
O
Outcome
Right ventricular systolic function (including pulmonary arterial end-systolic pressure, pulmonary vascular resistance, right ventricular end-systolic volume, and right ventricular ejection fraction)surrogate
Short-term intravenous amrinone improves right ventricular systolic function in patients with severe congestive heart failure, predominantly through afterload reduction.
Cite This Study
Konstam et al. (1986) studied this question.