Key result
Acute plasma volume expansion increases forearm blood flow via nitric oxide-dependent vasodilation.
Why the study?
Does acute plasma volume expansion increase peripheral arteriolar tone via nitric oxide in healthy subjects?
Does acute plasma volume expansion increase peripheral arteriolar tone via nitric oxide in healthy subjects?
Acute plasma volume expansion causes peripheral vasodilation in healthy subjects, an effect that is abolished by nitric oxide synthase inhibition, suggesting it is mediated by nitric oxide.
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NO mediates acute volume-induced vasodilation in healthy subjects; extends mechanistic insights but leaves open relevance to disease states.
Calver et al. (1992) studied Healthy. Acute plasma volume expansion (saline) and NG-monomethyl-L-arginine vs. Baseline was evaluated on Forearm blood flow response. Acute plasma volume expansion with 1000 ml of saline increased forearm blood flow, a vasodilator response that was abolished by the nitric oxide synthase inhibitor NG-monomethyl-L-arginine.
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