Why the study?
Does acute volume expansion by saline infusion increase plasma endothelin-1 levels in rats?
Does acute volume expansion by saline infusion increase plasma endothelin-1 levels in rats?
Acute volume load by rapid saline infusion significantly increases plasma endothelin-1 levels in rats, suggesting a compensatory vasoconstrictive mechanism against volume expansion.
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Supports compensatory endothelin-1 release in volume expansion; hypothesis-generating in rats and leaves open human relevance.
Saad Abdel-Sayed (2003) studied this question.
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