Key result
Amrinone, enoximone, and milrinone produce positive chronotropic, inotropic, and lusitropic effects without direct coronary vasodilation.
Why the study?
Do amrinone, enoximone, and milrinone have dissimilar concentration-dependent effects on cardiac function and metabolism in isolated guinea pig hearts?
Population
Isolated Langendorff perfused guinea pig hearts
Comparison
Amrinone, enoximone, and milrinone at… vs Comparison among the three phosphodiesterase…
Design
Preclinical
Authors
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Should not guide PDE3 inhibitor use in patients; leaves open translation of metabolic coronary flow mechanisms to humans.
Do amrinone, enoximone, and milrinone have dissimilar concentration-dependent effects on cardiac function and metabolism in isolated guinea pig hearts?
Milrinone has the most prominent effects on contractility and relaxation at clinically relevant concentrations among the tested PDE3 inhibitors, which increase coronary flow secondary to metabolic demand rather than direct vasodilation.
Zausig et al. (2006) studied Isolated Langendorff perfused guinea pig hearts. Phosphodiesterase type III inhibitors (amrinone, enoximone, milrinone) was evaluated on Electrophysiologic, mechanical, vasodilatory, and metabolic properties. In isolated guinea pig hearts, amrinone, enoximone, and milrinone produced dose-dependent positive chronotropic, inotropic, and lusitropic effects without directly causing coronary vasodilation.
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