Key result
Captopril induces glomerular diuresis and increases urea and chloride clearance in a perfused dogfish model.
Why the study?
Does captopril affect renal function in the European lesser-spotted dogfish trunk preparation?
Does captopril affect renal function in the European lesser-spotted dogfish trunk preparation?
The study provides physiological evidence suggesting the presence of an intrarenal renin-angiotensin system in the European lesser-spotted dogfish.
Indicates intrarenal renin-angiotensin system in elasmobranchs; hypothesis-generating and leaves open clinical translation.
The existence of an intrarenal renin‐angiotensin system (RAS) in a perfused European lesser‐spotted dogfish Scyliorhinus canicula trunk preparation was examined by the inhibition of angiotensin‐converting enzyme by captopril. This resulted in a glomerular diuresis, an increase in urea and chloride clearance and excretion, and an increase in transport maxima for glucose. It is proposed that these results suggest the presence of an intrarenal RAS.
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Wells et al. (2003) studied this question. Captopril was evaluated on Glomerular diuresis, urea and chloride clearance and excretion, and transport maxima for glucose. Inhibition of angiotensin-converting enzyme by captopril in a perfused dogfish trunk preparation resulted in glomerular diuresis and increased urea and chloride clearance.
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