Key result
Acute saline volume expansion in dogs increased atrial pressures, ANP, and sodium excretion in parallel, though sodium excretion remained elevated even as ANP decreased during stable volume expansion.
Population
Pentobarbital anesthetized dogs (n=10)
Design
Preclinical
Authors
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ANP contributes to acute but not sustained natriuresis in volume expansion; leaves open non-ANP mechanisms for human volume regulation studies.
ANP plays a role in modulating acute atrial volume overload, but non-ANP mechanisms are likely responsible for maintaining natriuresis during stable volume expansion.
Zimmerman et al. (1987) studied this question. Acute saline volume expansion was evaluated on Atrial pressure, ANP, renin-angiotensin-aldosterone system, and renal hemodynamic and excretory function. Acute saline volume expansion in dogs increased atrial pressures, ANP, and sodium excretion in parallel, though sodium excretion remained elevated even as ANP decreased during stable volume expansion.
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