Why the study?
Does acute volume expansion with saline infusion increase atrial natriuretic peptide and suppress plasma renin activity in men with moderate hypertension?
Population
8 men with moderate hypertension
Design
Other
Follow-up
10-20 minutes
Authors
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May link volume expansion to alpha-hANP-mediated renin suppression in hypertension; hypothesis-generating and requires prospective confirmation before clinical consideration.
Does acute volume expansion with saline infusion increase atrial natriuretic peptide and suppress plasma renin activity in men with moderate hypertension?
Acute volume expansion in hypertensive men increases alpha-hANP levels, which negatively correlates with plasma renin activity, suggesting alpha-hANP may partly mediate renin suppression.
Andersson et al. (1987) studied this question.
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