Key result
TNFSF4 rs3850641 AA genotype linked to ~100% greater MI risk versus the GG genotype.
Why the study?
Does the rs3850641 polymorphism of the TNFSF4 gene increase the risk of myocardial infarction in a Chinese Han population?
Case-Control (n=966)
Does the rs3850641 polymorphism of the TNFSF4 gene increase the risk of myocardial infarction in a Chinese Han population?
Odds Ratio: 2 (95% CI 1.04–3.86)
p-value: p=0.039
The rs3850641 polymorphism of the TNFSF4 gene is associated with an increased risk of myocardial infarction in the Chinese Han population.
Hypothesis-generating for TNFSF4 rs3850641 in Chinese Han MI risk; requires prospective validation before clinical consideration.
Tumor necrosis factor superfamily member 4 (TNFSF4), also known as Ox40 ligand (Ox40l), plays an important role in atherosclerosis development. Several studies reported the association between the rs3850641 polymorphism of the TNFSF4 gene and the risk of myocardial infarction (MI). However, the results are inconsistent. In order to explore the relationship between the rs3850641 polymorphism of the TNFSF4 gene and MI, we conducted a case–control study including 454 cases and 512 controls in a Chinese Han population. Genotyping was performed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The present study found that AA genotype (AA vs. GG: odds ratio (OR) & 95% confidence interval (CI), 2.00(1.04,3.86), P=0.039; AA vs. AG+GG: OR & 95% CI, 1.93(1.00,3.70), P=0.049) or A allele carriers (A vs. G: OR & 95% CI, 1.27(1.00,1.60), P=0.047) of the rs3850641 polymorphism of the TNFSF4 gene increased the risk of MI. In conclusion, this case–control study confirms that the rs3850641 polymorphism of the TNFSF4 gene increases the risk of MI.
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Chang-qing et al. (2018) conducted a case-control in Myocardial infarction (n=966). rs3850641 polymorphism of the TNFSF4 gene (AA genotype) vs. GG genotype was evaluated on Myocardial infarction (OR 2.00, 95% CI 1.04-3.86, p=0.039). The AA genotype of the TNFSF4 gene rs3850641 polymorphism was associated with an increased risk of myocardial infarction compared to the GG genotype (OR 2.00; 95% CI 1.04-3.86; P=0.039).
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