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January 1, 1994Journal of the Chemical Society Chemical Communications

A route to dipeptides containing β-amino-α-hydroxy acid fragments by coupling of N-boc-β-lactams with α-amino esters. Application to the synthesis of (–)-bestatin

Claudio Palomo J. M. Aizpurua Carmen Cuevas

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Abstract

α-Amino esters are smoothly acylated by N-Boc-3-alkoxy-4-alkyl-β-lactams in DMF under the influence of sodium azide, giving a novel dipeptide coupling reaction.

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Palomo et al. (1994) studied this question.

synapsesocial.com/papers/6aa474de3d8649a8032a15b3 https://doi.org/10.1039/c39940001957

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