Key result
During LVAD support in dogs, global right ventricular end-systolic elastance decreased from 2.4 to 1.7 mm Hg/mL (p<0.004), indicating impaired contractility with leftward septal shifting.
Why the study?
Does LVAD support alter global right ventricular systolic mechanics in closed-chest dogs?
Population
8 closed-chest, conscious, sedated dogs
Comparison
Left ventricular assist device support vs Baseline/lower levels of LVAD support
Design
Preclinical
Authors
Loading...
LVAD-induced RV contractility decline in dogs cautions against assuming neutral effects; leaves open human translation and efficiency preservation.
Does LVAD support alter global right ventricular systolic mechanics in closed-chest dogs?
Absolute Event Rate: 1.7% vs 2.4%
p-value: p=<0.004
During LVAD support, global RV contractility is impaired with leftward septal shifting, but RV myocardial efficiency and power output are maintained due to decreased RV afterload and increased RV preload.
Moon et al. (1993) studied Left ventricular assist device support (n=8). Left ventricular assist device (LVAD) support vs. Baseline (without full LVAD support) was evaluated on Global right ventricular end-systolic elastance (mm Hg/mL) (p=<0.004). During LVAD support in dogs, global right ventricular end-systolic elastance decreased from 2.4 to 1.7 mm Hg/mL (p<0.004), indicating impaired contractility with leftward septal shifting.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: