What question did this study set out to answer?

Determine the temporal presence and epidemiological prevalence of Chagas' disease in prehistoric South American populations across a 9,000-year record.

February 6, 2004Proceedings of the National Academy of SciencesOpen Access

A 9,000-year record of Chagas' disease

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Authors

AAArthur C. AufderheideUniversity of Minnesota, Duluth WSWilmar L. SaloUniversity of Minnesota MMMichael MaddenCommunity Medical Center

Discussion

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Implication

Paleogenetic study reveals persistent Trypanosoma cruzi infection in ancient Andean mummies, indicating endemic Chagas disease predated early human settlement.

Key Points

Determine the temporal presence and epidemiological prevalence of Chagas' disease in prehistoric South American populations across a 9,000-year record.
Examined tissue specimens from N=283 naturally desiccated human mummies representing 11 major cultural groups from northern Chile and southern Peru (spanning ~7050 B.C. to ~1500 A.D.).
Conducted PCR amplification and hybridization using a specific DNA probe targeted to kinetoplast DNA of Trypanosoma cruzi.
Detected Trypanosoma cruzi kinetoplast DNA in 41% of amplified tissue extracts across the total sample.
Identified no statistically significant differences in infection prevalence across cultural groups, age, sex, or specimen weight.

Cite This Study

Aufderheide et al. (2004) studied this question.

synapsesocial.com/papers/6aa4a6f86803e1e7a1f2d293 https://doi.org/10.1073/pnas.0307312101

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February 6, 2004Proceedings of the National Academy of SciencesOpen Access

A 9,000-year record of Chagas' disease

View Full Paper

Ask AI

Bookmark

Authors

AAArthur C. AufderheideUniversity of Minnesota, Duluth WSWilmar L. SaloUniversity of Minnesota MMMichael MaddenCommunity Medical Center

Discussion

Member takes

Implication

Paleogenetic study reveals persistent Trypanosoma cruzi infection in ancient Andean mummies, indicating endemic Chagas disease predated early human settlement.

Key Points

Determine the temporal presence and epidemiological prevalence of Chagas' disease in prehistoric South American populations across a 9,000-year record.
Examined tissue specimens from N=283 naturally desiccated human mummies representing 11 major cultural groups from northern Chile and southern Peru (spanning ~7050 B.C. to ~1500 A.D.).
Conducted PCR amplification and hybridization using a specific DNA probe targeted to kinetoplast DNA of Trypanosoma cruzi.
Detected Trypanosoma cruzi kinetoplast DNA in 41% of amplified tissue extracts across the total sample.
Identified no statistically significant differences in infection prevalence across cultural groups, age, sex, or specimen weight.

Cite This Study

Aufderheide et al. (2004) studied this question.

synapsesocial.com/papers/6aa4a6f86803e1e7a1f2d293 https://doi.org/10.1073/pnas.0307312101

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