Key result
High-fat diet in eNOS-deficient mice causes exaggerated hypertension and ~35% lower insulin sensitivity versus controls.
Why the study?
Does partial eNOS deficiency exacerbate insulin resistance and arterial hypertension in mice fed a high-fat diet?
Does partial eNOS deficiency exacerbate insulin resistance and arterial hypertension in mice fed a high-fat diet?
Effect estimate: 35% lower insulin-stimulated glucose utilization
Partial eNOS deficiency facilitates the development of insulin resistance and arterial hypertension during nutritional stress, highlighting the gene's role in linking metabolic and cardiovascular disease.
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Supports eNOS role in diet-induced metabolic-cardiovascular links in mice; hypothesis-generating, no human implications yet.
Cook et al. (2004) studied Insulin resistance and arterial hypertension. High-fat diet vs. Normal diet / control mice was evaluated on Insulin sensitivity and arterial pressure (35% lower insulin-stimulated glucose utilization). An 8-week high-fat diet in partial eNOS deficient mice caused exaggerated arterial hypertension and a 35% lower insulin-stimulated glucose utilization compared to control mice.
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