Key result
nCPAP therapy lowers 24-hour heart rate by ~4 bpm in patients with OSAHS.
Why the study?
Does nCPAP therapy reduce heart rate in patients with obstructive sleep apnoea-hypopnoea syndrome?
Does nCPAP therapy reduce heart rate in patients with obstructive sleep apnoea-hypopnoea syndrome?
Short-term nCPAP therapy significantly reduces 24-hour, daytime, and night-time heart rate in patients with obstructive sleep apnea, which may contribute to cardiovascular risk reduction.
Answers are grounded in this paper and cite their sources.
nCPAP was associated with lower heart rate in OSAHS; hypothesis-generating for CV risk reduction, needs RCT confirmation.
BACKGROUND: Elevated heart rate (HR) is a risk factor for cardiovascular disease. The effects of obstructive sleep apnoea-hypopnoea syndrome (OSAHS) on HR are controversial. AIM: To investigate the effect of nasal continuous positive airway pressure (nCPAP) therapy on HR in OSAHS patients. METHODS: Sixty-two OSAHS patients underwent 24-h electrocardiographic recording, both before and 3 or 4 days after instigation of nCPAP. RESULTS: After nCPAP was started, HR significantly decreased (mean +/- SD 71.8 +/- 10.6 vs. 67.5 +/- 9.4 bpm, p < 0.0001), both in the daytime (0600-2200 h, 76.3 +/- 12.2 vs. 72.2 +/- 10.2 bpm, p < 0.0001) and at night-time (2200-0600 h, 64.5 +/- 9.1 vs. 60.0 +/- 8.9 bpm, p < 0.0001). HR was significantly reduced in both periods in the 44 patients with hypertension and/or diabetes mellitus, but only during the night-time in the 18 with neither condition. Before nCPAP treatment, HR was positively correlated with percentage time of arterial O2 saturation <90% during sleep (p = 0.008) and with the apnoea-hypopnoea index during sleep (p = 0.003). In 15 patients undergoing HR for 2 days before starting nCPAP, the mean HRs for the two periods were similar (p = 0.95). DISCUSSION: nCPAP therapy appears to decrease HR in OSAHS patients, and may thereby reduce their risk of cardiovascular disease.
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Kensuke Sumi (2006) studied obstructive sleep apnoea-hypopnoea syndrome (OSAHS) (n=62). nasal continuous positive airway pressure (nCPAP) vs. Before nCPAP treatment was evaluated on 24-hour heart rate (p=< 0.0001). Nasal continuous positive airway pressure (nCPAP) therapy significantly decreased mean 24-hour heart rate from 71.8 bpm to 67.5 bpm (p < 0.0001) in patients with OSAHS.
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