Key result
SHAPE probing coupled with computer prediction successfully determines secondary structures of five Pospiviroidae viroids.
Population
Five viroids belonging to four genera of the Pospiviroidae family
Design
Preclinical
Authors
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May advance viroid RNA structure studies; leaves open functional validation and plant disease applications.
SHAPE probing coupled with computer-assisted prediction is a novel approach for determining the secondary structures of viroids in solution.
Xú et al. (2012) studied Viroid structure (n=5). SHAPE probing coupled to computer-assisted structure prediction was evaluated on Secondary structures of five viroids. SHAPE probing coupled to computer-assisted structure prediction successfully determined the secondary structures of five viroids belonging to four genera of the Pospiviroidae family.
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