Key result
Perindopril prevents MI-induced skeletal muscle mitochondrial dysfunction in rats.
Why the study?
Does perindopril prevent skeletal muscle mitochondrial dysfunction in rats with myocardial infarction?
Population
Rats with myocardial infarction (MI) induced by left descending coronary artery ligation
Comparison
Perindopril 2 mg.kg.day given 7 days after MI vs Sham surgery and untreated MI rats
Design
Preclinical
Follow-up
1 and 4 months
Authors
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May protect skeletal muscle mitochondria post-MI in rats; leaves open human translation and clinical relevance.
Does perindopril prevent skeletal muscle mitochondrial dysfunction in rats with myocardial infarction?
ACE inhibition with perindopril prevents MI-induced skeletal muscle mitochondrial dysfunction and preserves mitochondrial transcriptional factors in a rat model.
Zoll et al. (2006) studied Myocardial infarction. Perindopril vs. Sham and untreated MI was evaluated on Oxygen consumption of white gastrocnemius muscle and mitochondrial function. Perindopril treatment in rats with myocardial infarction totally prevented MI-induced alterations of skeletal muscle mitochondrial function and protein expression.
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