Key result
Adding daily insulin to sulfonylureas may restore glycemic control in uncontrolled T2D under 15 years.
Why the study?
Does the addition of a single daily injection of insulin improve glycemic control in patients with type II diabetes mellitus failing diet and sulfonylurea?
Does the addition of a single daily injection of insulin improve glycemic control in patients with type II diabetes mellitus failing diet and sulfonylurea?
Adding a single daily injection of insulin is a viable strategy for type II diabetes patients failing diet and sulfonylurea therapy.
Supports insulin addition in shorter-duration type 2 diabetes failing sulfonylureas; leaves open prospective RCT confirmation.
Non-insulin-dependent (type II) diabetes mellitus is a progressive disease that requires sequential therapy to achieve optimal control. When diet and sulfonylurea fail to maintain glycemic control, the addition of a single daily injection of insulin may be indicated. The best candidates for this combined therapy are patients with typical adult-onset disease that has been present less than 10 to 15 years.
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M. Riddle (1992) conducted a review in Non-insulin-dependent (type II) diabetes mellitus. Addition of a single daily injection of insulin to sulfonylurea was evaluated. The addition of a single daily injection of insulin to sulfonylurea therapy may be indicated for patients with type II diabetes present for less than 10 to 15 years who fail to maintain glycemic control.
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