Enantioenriched calcium complexes mediated efficient synthesis of (S)-(+)-fenoprofen

An efficient chiral catalyst for the asymmetric epoxidation of α,βunsaturated carbonyl compounds is developed utilizing easily available, eco-friendly CaCl 2 and chiral ligand.Efficacy of the methodology is extended for the stereoselective synthesis of (S)-Fenoprofen.A survey of ligands indicated that (S)-,6,6'-Diphenyl BINOL-Ca 1e was the best ligand giving maximum ee (84%) for 4 with excellent yield.