Key result
Atriopeptins relax human coronary arteries in vitro and elevate cGMP levels ~3-fold.
Why the study?
Do atriopeptins induce relaxation and increase cyclic GMP levels in human coronary arteries in vitro?
Population
Human coronary artery in vitro
Design
Preclinical
Authors
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Hypothesis-generating for coronary vasomotor control; leaves open any clinical translation without in vivo data.
Do atriopeptins induce relaxation and increase cyclic GMP levels in human coronary arteries in vitro?
Atriopeptins induce relaxation and increase cyclic GMP levels in human coronary arteries in vitro, suggesting a potential role in coronary vasodilation.
Rapoport et al. (1986) studied Human coronary artery in vitro. Atriopeptins (alpha-Atrial natriuretic polypeptide and atriopeptins I, II and III) was evaluated on Relaxation and cyclic GMP levels. Atriopeptins induced relaxation in human coronary arteries in vitro and elevated cyclic GMP levels 2- to 3-fold.
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