Key result
Severe COPD is linked to a ~500% higher risk of left ventricular diastolic dysfunction.
Why the study?
Is COPD associated with an increased risk of left ventricular diastolic dysfunction in patients with preserved ejection fraction?
Population
230 patients with an LV ejection fraction of ≥50%, mean age 74.4±10.4 years, 72.3% men.
Comparison
COPD (observational exposure) vs Age- and sex-matched control patients without COPD
Design
Case-control
Authors
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Hypothesis-generating for diastolic dysfunction screening in severe COPD; prospective studies needed before clinical adoption.
Case-Control (n=230)
Is COPD associated with an increased risk of left ventricular diastolic dysfunction in patients with preserved ejection fraction?
Odds Ratio: 6 (95% CI 2.08–17.35)
Absolute Event Rate: 11.3% vs 4.3%
p-value: p=0.001
Severe COPD is strongly associated with left ventricular diastolic dysfunction, potentially due to mechanical exclusion of the heart by pulmonary overinflation.
Kubota et al. (2016) conducted a case-control in COPD and left ventricular diastolic dysfunction (n=230). COPD vs. Age- and sex-matched controls was evaluated on High E/e' (≥15) (OR 6.00, 95% CI 2.08-17.35, p=0.001). COPD was associated with a higher prevalence of left ventricular diastolic dysfunction (11.3% vs 4.3%), with severe COPD strongly predicting high E/e' (OR 6.00; 95% CI 2.08-17.35; P=0.001).
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