What is the clinical evidence from this study?

Study design: Observational. Population: Coronary artery bypass surgery (n=30). Intervention: Pressure controlled intermittent coronary sinus occlusion (PISCO). Primary outcome: Quantitative assessment of human coronary sinus pressure dynamics and adequacy of occlusion/release cycle lengths.

What question did this study set out to answer?

To quantitatively evaluate coronary sinus pressure dynamics in cardiac surgery patients and determine whether mathematical modeling can replace visual interpretation to guide occlusion cycling.

April 1, 1988Cardiovascular Research

Intermittent coronary sinus occlusion in humans: pressure dynamics and calculation of diagnostic quantities

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Key result

Mathematical analysis of PICSO dynamics provides numerical estimates for closed-loop adjustment of occlusion cycling.

n=30

Why the study?

Can a mathematical model accurately assess coronary sinus pressure dynamics and replace visual control for adjusting pressure controlled intermittent coronary sinus occlusion (PISCO) in patients undergoing coronary artery bypass surgery?

Population

30 patients undergoing coronary artery bypass surgery

Design

Case_series

Authors

WSWolfgang SchreinerStatistics Austria FNFrank NeumannForma Therapeutics (United States)JSJ. SchusterUniversity of Vienna

Discussion

Member takes

Implication

May enable automated PISCO cycling in CABG; hypothesis-generating pending prospective validation.

Key Points

To quantitatively evaluate coronary sinus pressure dynamics in cardiac surgery patients and determine whether mathematical modeling can replace visual interpretation to guide occlusion cycling.
Applied pressure-controlled intermittent coronary sinus occlusion with visual monitoring of pressure waveforms to manually adjust cycle timing in 30 patients undergoing coronary artery bypass surgery.
Digitized intraoperative coronary sinus pressure data in a subset of 6 patients for postoperative mathematical analysis to automatically detect systolic peaks, diastolic troughs, and derived variables.
Generated intraindividual and interindividual mathematical estimates of derived pressure variables, correlating automated waveform detection with underlying cardiovascular physiology.
Identified optimal statistical and computational methods to replace manual visual inspection, providing the quantitative framework required for automated closed-loop occlusion cycling.

Study Design

Type

Observational (n=30)

Structured PICO

Population

30 patients undergoing coronary artery bypass surgery.

Intervention

Pressure controlled intermittent coronary sinus occlusion (PISCO) with manual adjustment of occlusion and release times, including postoperative mathematical analysis of digitised measurements in a subset of 6 patients

Outcome

Quantitative assessment of human coronary sinus pressure dynamics, evaluation of whether visual control could be replaced by a mathematical model, and adequacy of occlusion and release cycle lengthssurrogate

Mathematical analysis of coronary sinus pressure dynamics during PISCO provides a numerical basis for automated, closed-loop adjustment of occlusion cycling during coronary artery bypass surgery.

Cite This Study

Schreiner et al. (1988) conducted an observational in Coronary artery bypass surgery (n=30). Pressure controlled intermittent coronary sinus occlusion (PISCO) was evaluated on Quantitative assessment of human coronary sinus pressure dynamics and adequacy of occlusion/release cycle lengths. Mathematical analysis of pressure controlled intermittent coronary sinus occlusion dynamics provided numerical estimates that form the basis for closed loop adjustment of occlusion cycling.

synapsesocial.com/papers/6aa4d9b2af1d3d7e5b0a4a1e https://doi.org/10.1093/cvr/22.4.277

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Intermittent coronary sinus occlusion in humans: pressure dynamics and calculation of diagnostic quantities

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Intermittent coronary sinus occlusion in humans: pressure dynamics and calculation of diagnostic quantities

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

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