What is the clinical evidence from this study?

Study design: Other. Population: Cardiovascular deconditioning. Intervention: Tail suspension. Primary outcome: Blood pressure (BP) and heart rate (HR) responses, spectral properties, and baroreceptor reflex sensitivity.

What does this research mean for the field?

Long-term tail suspension in rats does not induce cardiovascular deconditioning, changes in cardiovascular variability, or altered baroreceptor reflex sensitivity, questioning its validity as a model for spaceflight-induced cardiovascular changes in humans. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

February 1, 1995Journal of Applied Physiology

Cardiovascular variability and baroreceptor reflex sensitivity over a 14-day tail suspension in rats

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Key result

Rat tail suspension fails to alter BP or HR, suggesting an invalid human spaceflight model.

or 13

Population

male Wistar rats

Design

Preclinical

Follow-up

14 days

Authors

SFS. FagetteUniversité Claude Bernard Lyon 1 MLMing LoUniversité Claude Bernard Lyon 1 CGC. GharibHôpital Edouard Herriot

Discussion

Member takes

Implication

Questions tail suspension as a model for spaceflight cardiovascular changes; leaves open identification of valid alternatives for research.

Structured PICO

Population

Male Wistar rats subjected to 13 days of tail suspension and 24-h recovery to simulate long-term weightlessness.

Intervention

tail suspension for 13 days followed by a 24-h recovery

Outcome

Blood pressure (BP) and heart rate (HR) responses, their spectral properties, and pharmacologically tested baroreceptor reflex sensitivitysurrogate

Long-term tail suspension in rats does not induce cardiovascular deconditioning, suggesting it is not a valid model for studying spaceflight-induced cardiovascular alterations in humans.

Cite This Study

Fagette et al. (1995) studied Cardiovascular deconditioning. Tail suspension was evaluated on Blood pressure (BP) and heart rate (HR) responses, spectral properties, and baroreceptor reflex sensitivity. Tail suspension for 13 days in male Wistar rats did not alter blood pressure, heart rate, or baroreceptor reflex sensitivity, suggesting it may not be a valid model for human spaceflight.

synapsesocial.com/papers/6aa4dc7dc19a1092ac81209b https://doi.org/10.1152/jappl.1995.78.2.717

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February 1, 1995Journal of Applied Physiology

Cardiovascular variability and baroreceptor reflex sensitivity over a 14-day tail suspension in rats

View Full Paper

Ask AI

Bookmark

Key result

Rat tail suspension fails to alter BP or HR, suggesting an invalid human spaceflight model.

or 13

Population

male Wistar rats

Design

Preclinical

Follow-up

14 days

Authors

SFS. FagetteUniversité Claude Bernard Lyon 1 MLMing LoUniversité Claude Bernard Lyon 1 CGC. GharibHôpital Edouard Herriot

Discussion

Member takes

Implication

Questions tail suspension as a model for spaceflight cardiovascular changes; leaves open identification of valid alternatives for research.

Structured PICO

Population

Male Wistar rats subjected to 13 days of tail suspension and 24-h recovery to simulate long-term weightlessness.

Intervention

tail suspension for 13 days followed by a 24-h recovery

Outcome

Blood pressure (BP) and heart rate (HR) responses, their spectral properties, and pharmacologically tested baroreceptor reflex sensitivitysurrogate

Long-term tail suspension in rats does not induce cardiovascular deconditioning, suggesting it is not a valid model for studying spaceflight-induced cardiovascular alterations in humans.

Cite This Study

synapsesocial.com/papers/6aa4dc7dc19a1092ac81209b https://doi.org/10.1152/jappl.1995.78.2.717

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