Key result
Release from tail suspension increases baroreceptor reflex sensitivity, unaffected by intravenous V2 antagonists.
Why the study?
Does V2-receptor antagonism alter baroreceptor reflex sensitivity after tail suspension in conscious rats?
Population
Conscious chronically instrumented rats
Comparison
1 week of 30 degrees head-down tilt resulting… vs Baseline (before tail suspension)
Design
Preclinical
Follow-up
7 days
Authors
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V2 antagonism does not modify post-suspension baroreflex recovery in rats; leaves open vasopressin's role in microgravity-related autonomic changes.
Does V2-receptor antagonism alter baroreceptor reflex sensitivity after tail suspension in conscious rats?
V2-vasopressinergic receptors do not appear to contribute to the alteration of baroreceptor reflex sensitivity following 1 week of tail suspension in conscious rats.
Brizzee et al. (1990) studied this question. Tail suspension and V2-receptor antagonist vs. Baseline/Control was evaluated on Baroreceptor reflex (BRR) sensitivity. Baroreceptor reflex sensitivity significantly increased after release from 1 week of tail suspension but was not altered by intravenous V2 antagonist administration.
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