Key result
Metoprolol safely lowers resting HR without airway obstruction in asthmatic, thyrotoxic patients preparing for thyroidectomy.
Why the study?
Does metoprolol reduce resting heart rate without inducing airway obstruction in asthmatic, thyrotoxic patients preparing for thyroidectomy?
Case Report (n=2)
Does metoprolol reduce resting heart rate without inducing airway obstruction in asthmatic, thyrotoxic patients preparing for thyroidectomy?
Metoprolol can be effectively used to reduce resting heart rate in asthmatic, thyrotoxic patients preparing for thyroidectomy without causing significant airway obstruction, though close monitoring is required.
May support metoprolol with close monitoring in this setting; leaves open generalizability beyond N=2.
Metoprolol, a cardioselective beta-blocker, was used in two asthmatic, thyrotoxic patients in preparation for thyroidectomy. Adequate reduction in resting heart rate was achieved in both individuals without inducing clinically significant airway obstruction. Beta-1-blockade can be selectively employed in this clinical setting, but patients should be hospitalized and closely monitored for adverse effects on pulmonary function. Metoprolol therapy in patients with reversible airway obstruction is discussed with reference to recent studies on relative cardioselectivity.
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Dial et al. (1982) conducted a case report in Asthmatic, thyrotoxic patients (n=2). Metoprolol was evaluated on Reduction in resting heart rate and airway obstruction. Metoprolol achieved adequate reduction in resting heart rate in two asthmatic, thyrotoxic patients preparing for thyroidectomy without inducing clinically significant airway obstruction.
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