Key result
Whole genome sequencing of a novel bat rotavirus strain reveals a genotype indicating interspecies transmission.
Identification of a multi-reassortant group A rotavirus in a Zambian bat suggests interspecies transmission and genomic reassortment between bats and other mammals.
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Detects reassortant rotavirus in bats; leaves open zoonotic risk and need for surveillance studies.
Group A rotavirus is a major cause of diarrhoea in humans, especially in young children. Bats also harbour group A rotaviruses, but the genetic backgrounds of bat rotavirus strains are usually distinct from those of human rotavirus strains. We identified a new strain of group A rotavirus in the intestinal contents of a horseshoe bat in Zambia. Whole genome sequencing revealed that the identified virus, named RVA/Bat-wt/ZMB/LUS12-14/2012/G3P[3], possessed the genotype constellation G3-P[3]-I3-R2-C2-M3-A9-N2-T3-E2-H3. Several genome segments of LUS12-14 were highly similar to those of group A rotaviruses identified from humans, cows and antelopes, indicating interspecies transmission of rotaviruses between bats and other mammals with possible multiple genomic reassortment events.
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Sasaki et al. (2016) studied Group A rotavirus (n=1). Whole genome sequencing of rotavirus strain was evaluated on Genomic characterization of the rotavirus strain. Whole genome sequencing of a new group A rotavirus strain from a horseshoe bat in Zambia revealed a G3-P[3]-I3-R2-C2-M3-A9-N2-T3-E2-H3 genotype constellation, indicating interspecies transmission.
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