January 12, 2023Journal of VirologyOpen Access

Isolation and Characterization of Distinct Rotavirus A in Bat and Rodent Hosts

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Why the study?

Most newly discovered divergent RVAs have been identified only via viral genomes without infectious virus isolation, leaving virological properties such as tropisms, transmissibility, and pathogenicity unclear.

Population

RVAs isolated from three bats and one rodent in Zambia

Design

Preclinical virological isolation and characterization study

Authors

MKMai KishimotoOsaka Prefecture University MKMasahiro KajiharaHokkaido University KTKoshiro TabataHokkaido University of Science

Discussion

Member takes

Implication

Novel RVA genome detections warrant caution interpreting non-infectious data; leaves open tropism, transmissibility, and pathogenicity pending infectious isolates.

Structured PICO

Population

Three bats and one rodent in Zambia, as well as mice and human gut 3D culture of primary intestinal epithelium models.

Intervention

Isolation and characterization of distinct Rotavirus A (RVA) strains (whole-genome sequencing, glycan-binding affinity, pathogenicity in mice, and infectivity to human gut).

Outcome

Virological properties including glycan-binding affinity, pathogenicity in mice, and infectivity to the human gut.surrogate

The study provides the first virological characterization of bat and rodent rotaviruses, offering basic knowledge to estimate their zoonotic transmission potential.

Cite This Study

Kishimoto et al. (2023) studied this question.

synapsesocial.com/papers/6a6faa7ae5469ee92be08a34 https://doi.org/10.1128/jvi.01455-22

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Implication

Novel RVA genome detections warrant caution interpreting non-infectious data; leaves open tropism, transmissibility, and pathogenicity pending infectious isolates.